This site is intended for
US Healthcare Professionals only.

Treatment Eligibility

ARE YOUR PATIENTS ELIGIBLE FOR SYMDEKO® (tezacaftor/ivacaftor and ivacaftor)?

Enter your patient's mutations below to see if they are eligible for SYMDEKO.

SYMDEKO is indicated for the treatment of patients with cystic fibrosis (CF) age 6 years and older who are homozygous for the F508del mutation or who have at least one mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is responsive to tezacaftor/ivacaftor based on in vitro data and/or clinical evidence.

1.
Mutation 1
Mutation 2

Please check to see if the mutation was entered correctly.

Add Row

Please check to see if the mutation was entered correctly.

Learn how to enter 2 or more mutations

 

Alternatively, please see the responsive mutations below:

Bold = Newly approved mutations. December 2020.

CFTR Mutations That Produce CFTR Protein and Are Responsive to SYMDEKO 1-3

546insCTA

F575Y

L346P

R553Q

711+3A→G*

F1016S

L967S

R668C

2789+5G→A*

F1052V

L997F

R751L

3272-26A→G*

F1074L

L1324P

R792G

3849+10kbC→T*

F1099L

L1335P

R933G

A120T

G126D

L1480P

R1066H

A234D

G178E

M152V

R1070Q

A349V

G178R

M265R

R1070W*

A455E*

G194R

M952I

R1162L

A554E

G194V

M952T

R1283M

A1006E

G314E

P5L

R1283S

A1067T

G551D

P67L*

S549N

D110E

G551S

P205S

S549R

D110H*

G576A

Q98R

S589N

D192G

G576A;
R668C

Q237E

S737F

D443Y

G622D

Q237H

S912L

D443Y;G576A;R668C

G970D

Q359R

S945L*

D579G*

G1069R

Q1291R

S977F*

D614G

G1244E

R31L

S1159F

D836Y

G1249R

R74Q

S1159P

D924N

G1349D

R74W

S1251N

D979V

H939R

R74W;
D1270N

S1255P

D1152H*

H1054D

R74W;V201M

T338I

D1270N

H1375P

R74W;V201M;D1270N

T1036N

E56K

I148T

R75Q

T1053I

E60K

I175V

R117C*

V201M

E92K

I336K

R117G

V232D

E116K

I601F

R117H

V562I

E193K

I618T

R117L

V754M

E403D

I807M

R117P

V1153E

E588V

I980K

R170H

V1240G

E822K

I1027T

R258G

V1293G

E831X

I1139V

R334L

W1282R

F191V

I1269N

R334Q

Y109N

F311del

I1366N

R347H*

Y161S

F311L

K1060T

R347L

Y1014C

F508C

L15P

R347P

Y1032C

F508C;
S1251N

L206W*

R352Q*

    

F508del

L320V

R352W

     

*Clinical data for these mutations appears in Clinical Studies can be found here and here or within section 14.1 and 14.2 of the Prescribing Information.
†A patient must have 2 copies of the F508del mutation or at least 1 copy of a responsive mutation listed above in this table to be indicated for SYMDEKO.
‡Complex/compound mutations in which a single allele of the CFTR gene has multiple mutations; these exist independent of the presence of mutations on the other allele.